This just in from Integramed's Conception e-newsletter:
Can We Wait to Get Pregnant?
By Michael Soules, M.D.
In
these difficult economic times many couples, who otherwise would be
attempting to get pregnant now, are asking themselves whether they can
wait to get pregnant and not jeopardize their chances to have a baby.
The answer is: it depends.
If
the couple's medical history indicates a likelihood of infertility then
it is best not to wait. Some clues that could indicate a fertility
problem are:
- Irregular menstrual periods.
- Menstrual pain that is becoming progressively worse.
- A prior sexually transmitted infection in either partner.
- Too many past episodes where lapses in contraception didn't result in a pregnancy.
For
the female partner there is a loss of fertility potential as she gets
older. On average a woman's peak fertility is in her late 20's;
decreases somewhat to age 35; and decreases sharply after 35.
| Percent |
20-24 |
25-29 |
30-34 |
35-39 |
40-44 |
45-49 |
| Pregnant the First Year |
48% |
43% |
40% |
35% |
17% |
4% |
| Eventually Pregnant |
94% |
91% |
85% |
70% |
36% |

Fig 1. This is a figure from a famous study by Menken (Science; 23,
1389; 1986) who reported on the birth rate of normal couples in
populations who did not use contraception and kept good birth records.
Whether it is the "eventually pregnant" or the "pregnant the 1st year"
curve, note the steep slope after age 35.
However, these are average ages for a population of women. When it comes to an individual
woman, her fertility may be better or worse than the population average
for her age. In other words, two women who are the same chronological
age may very well be quite different in terms of their fertility
potential.
The
ovary has a functional age wherein it ages to extinction at menopause.
There is a wide range for normal menopause from age 42 to 58 years
which reflects wide variation in ovarian aging amongst women.
Considering the fact that fertility is moderately to severely
compromised beginning 10 years prior to menopause, a woman in her mid 30's could already be infertile or still have a number of fertile years remaining.
Women
over 30 who want to delay conception should be advised to assess their
functional ovarian age (ovarian reserve) in order to make an informed
decision. We recommend using two approaches (endocrine and anatomic) to
estimate ovarian reserve.
Endocrine: a cycle day 3 FSH and estradiol level are measured with simple blood tests.
Anatomic: an ovarian ultrasound examination wherein the number of small
follicles present (antral follicle count) gives a good approximation of
the current total number of eggs in both ovaries (approximately 800,000
at birth; 0 at menopause).
While fertility still decreases with age even with
normal ovarian reserve, it wouldn't be unreasonable to wait 6 to 18
months to attempt conception if her reserve is normal and she is
younger than 38 years old. After age 38, it is not a good idea to delay
conception if pregnancy is at all possible.
There
are only minimal age issues in terms of sperm production and fertility
in normal men until they are truly elderly. However, young men of
reproductive age can have abnormal sperm production that does get worse
as they age if they have other medical conditions. The best example
would be a relatively common male fertility problem wherein there is a
subtle dilatation of the veins (varicocele) draining one or both
testicles. In this case the testicular damage increases over time and
sperm production becomes further compromised as the man gets older.
The simplest way to check to see if there are any sperm problems is to have a semen analysis.
Figure 2 is a side-by-side comparison of semen analysis results from a normal fertile man compared to a man with a varicocele
| FIG2 | Normal | Varicocele | Range |
|---|
| Volume (ml) |
3.5 |
2.8 |
3-5 ml |
| Concentration (x106/ml) |
64 |
16 |
20-250 |
| Motility (%) |
57 |
35 |
≥50% |
| Rapid & Linear (%) |
18 |
4 |
≥15% |
| Morphology |
39 |
11 |
≥30% |
Fig
2. Normal semen analysis (left column); Semen Analysis from a man with
a varicocele (right column). A man with a varicocele generally has
decreased count, motility and morphology as seen here.
For a
couple who wants to seriously consider postponing their fertility, it
is recommended that the female partner have an assessment of her
ovarian reserve and the male partner have a semen analysis. Ideally,
both of these tests would be performed and/or interpreted by a
reproductive endocrinologist or an Ob/Gyn physician who has this
expertise.
For some, waiting it out through tough times may be an acceptable option. Others may feel pressed to make hard choices.
Dr. Michael Soules established his
practice in reproductive endocrinology at the University of Washington in 1980. He now leads the fertility expert team at
Seattle Reproductive Medicine.
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